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Goal-directed behavior involves a continuous loop of perceptions and actions, and integration of multiple cognitive process. For example, the simple act of opening a door requires the representation of an intention (do I want to exit the room or allow someone in), action-selection (should I use my palm or rather my elbow to avoid possible COVID infection?), and perception (for successful control of the limb with respect to the door-handle). With respect to motor control, these processes are non-trivial since there is no one-to-one mapping between actions and outcome, and this relationship is highly dependent on context. For example, when the car gear is set to reverse, the same action of pressing the gas paddle (and corresponding motor commands) has completely different consequences. In my lab, we use neuroimaging (fMRI/EEG), VR and various behavioral measures to explore how the brain generates voluntary movement and purposeful behavior.

News

Latest Publications:

Same Action, Different Meaning: Neural Substrates of Action Semantic Meaning – Aberbach-Goodman, S., Buaron, B., Mudrik, L. & Mukamel, R., Cerebral Cortex, 2022

Real-time processes in the development of action planning – Ossmy, O., Kaplan, B.E., Han, D., Xu, M., Bianco, C., Mukamel, R. & Adolph, K.E.,  Current Biology, 2022

Children do not distinguish efficient from inefficient actions during observation – Ossmy, O., Han, D., Kaplan, B.E., Xu, M., Bianco, C., Mukamel, R. & Adolph, K.E., Scientifc Reports 2021

Our Lab in the News:

English:

Prof. Roy Mukamel receives the Kadar Family Award for Outstanding Research at Tel Aviv University

3D Virtual Reality Therapy Could Help Repair Damaged Limbs- ‘NoCamels’, Feb 2017

Scientists harness virtual reality to teach damaged limbs new tricks- ‘Haaretz’, Dec 2016

New study reveals your left hand DOES know what your right is doing- Sunday Express, Dec 2016

New Israeli virtual reality tech could rehabilitate damaged limbs, stroke patients- The Jerusalem Post, Dec 2016

Hebrew:

How actions and their sensory consequences are represented in the human brain- ISF, July 2019

Prof. Roy Mukamel receives the Kadar Family Award for Outstanding Research

Improvement of motor abilities using virtual reality- ‘Haaretz’, Dec 2016

Improvement of motor abilities using virtual reality- Ynet, Dec 2016 

Improvement of motor abilities using virtual reality- ‘Mabat’, Dec 2016

Improvement of motor abilities using virtual reality- Weizmann institute of science, Dec 2016


Insight from Inside: Intracranial studies of the human brain conference (30.11-1.12.2016)


Lab Members

Alumni

Publications

2022

Same Action, Different Meaning: Neural Substrates of Action Semantic Meaning – Aberbach-Goodman, S., Buaron, B., Mudrik, L. & Mukamel, R., Cerebral Cortex, 2022

Real-time processes in the development of action planning – Ossmy, O., Kaplan, B.E., Han, D., Xu, M., Bianco, C., Mukamel, R. & Adolph, K.E.,  Current Biology, 2022

2021

Children do not distinguish efficient from inefficient actions during observation – Ossmy, O., Han, D., Kaplan, B.E., Xu, M., Bianco, C., Mukamel, R. & Adolph, K.E., Scientifc Reports 2021

Action-locked neural responses in auditory cortex to self-generated sounds – Reznik, D.,  Guttman, N., Buaron, B., Zion-Golumbic, E. & Mukamel, R., Cerebral Cortex 2021

2020

Single-cell activity in human STG during perception of phonemes is organized according to manner of articulation – Lakertz, Y., Ossmy, O., Friedmann, N., Mukamel, R. & Fried, I., NeuroImage 2020

Motor learning in hemi-Parkinson using VR-manipulated sensory feedback – Ossmy O., Mansano L., Frenkel-Toledo S., Kagan E., Koren S., Gilron R., Reznik D., Soroker S. &  Mukamel R., Disability and Rehabilitation 2020

Voluntary actions modulate perception and neural representation of action-consequences in a hand-dependent manner– Buaron B., Reznik D., Gilron R., Mukamel R., Cerebral Cortex 2020

2019

Better-than-chance classification for signal detection– Rosenblatt, J. D., Benjamini, Y., Gilron, R., Mukamel, R., & Goeman, J. J., Biostatistics, 2019

Motor output, neural states and auditory perception– Reznik, D. & Mukamel, R., Neuroscience & Biobehavioral Reviews, 2019

2018

A novel tool for time-locking study plans to results– Mazor, M., Mazor, N. & Mukamel, R.,  European Journal of Neuroscience, 2018

Predicted sensory consequences of voluntary actions modulate amplitude of preceding readiness potentials– Reznik, D., Simon, S. & Mukamel, R., Neuropsychologia, 2018

Suppression of EEG Mu Rhythm During Action Observation Corresponds with Subsequent Changes in Behavior– Aridan, N., Ossmy, O., Buaron, B., Reznik, D. & Mukamel, R., Brain Research, 2018

Perception as a Route for Motor Skill Learning: Perspectives from Neuroscience– Ossmy, O. & Mukamel, R., Neuroscience, 2018

Behavioral and Neural Effects of Congruency of Visual Feedback During Short-Term Motor Learning– Ossmy, O. & Mukamel, R., NeuroImage, 2018

2017

Using Virtual Reality to Transfer Motor Skill Knowledge from One Hand to Another– Ossmy, O. & Mukamel, R.,  J. Vis. Exp., 2017

Sensitivity to perception level differentiates two subnetworks within the mirror neuron system– Simon, S. & Mukamel, R.,  SCAN 2017

What’s in a pattern? Examining the type of signal multivariate analysis uncovers at the group level– Gilron, R., Rosenblatt, J., Koyejo, O., Poldrack, R.A. & Mukamel, R., NeuroImage 2017

Short Term Motor-Skill Acquisition Improves with Size of Self-Controlled Virtual Hands– Ossmy, O. & Mukamel, R., Plos One 2017

2016

Neural Network Underlying Intermanual Skill Transfer in Humans– Ossmy, O. & Mukamel, R., Cell Reports 2016

Activity in primary motor cortex during action observation covaries with subsequent behavioral changes in execution– Aridan, N. & Mukamel, R.,  Brain and Behavior 2016

Activity in superior parietal cortex during training by observation predicts asymmetric learning levels across hands– Ossmy, O. & Mukamel, R., Scientific Reports 2016

Power modulation of electroencephalogram mu and beta frequency depends on perceived level of observed actions– Simon S. & Mukamel, R., Brain and Behavior 2016

2015

Decoding speech perception from single cell activity in humans– Ossmy, O., Fried, I. & Mukamel, R., NeuroImage 2015

Preconscious prediction of a driver’s decision using intracranial recordings– Perez, O., Mukamel, R., Tankus, A., Rosenblatt, J.D., Yeshurun, Y. & Fried, I., Journal of Cognitive Neuroscience 2015

Perceived loudness of self-generated sounds is differentially modified by expected sound intensity– Reznik, D., Henkin, Y., Levy, O. & Mukamel, R., Plos One 2015

Enhanced auditory evoked activity to self-generated sounds is mediated by primary and supplementary motor cortices– Reznik, D., Ossmy, O. & Mukamel, R., Journal of Neuroscience 2015

Invited Book Chapter

“Neural correlates of intentions” in “Human Agency: Functions and Mechanisms”– Gilron R., Simon S. & Mukamel R. Editors Eitam B. & Haggard P., Oxford University Press, 2015

2014

Differentiating intended sensory outcome from underlying motor actions in the human brain– Krasovsky, A., Gilron, R., Yeshurun, Y. & Mukamel, R., Journal of Neuroscience 2014

Decoding letter position in word reading– Ossmy, O., Ben-Shachar, M. & Mukamel, R., Cortex 2014

Lateralized enhancement of auditory cortex activity and increased sensitivity to self-generated sounds– Reznik, D., Henkin, Y., Schadel, N. & Mukamel, R., Nature Communications 2014

2012

Memory enhancement and deep-brain stimulation of the entorhinal area– Suthana, N., Haneef, Z., Stern, J., Mukamel, R., Behnke, E., Knowlton, B. & Fried, I., New England Journal of Medicine 2012

2011

Human intracranial recordings and cognitive neuroscience– Mukamel, R. & Fried, I., Annual Review of Psychology 2011

Invariance of firing rate and field potential dynamics to stimulus modulation rate in human auditory cortex– Mukamel, R., Nir, Y., Harel, M., Arieli, A., Malach, R. & Fried, I., Human Brain Mapping 2011

Internally generated preactivation of single neurons in human medial frontal cortex predicts volition– Fried, I., Mukamel, R. & Kreiman, G., Neuron 2011

2010

Single-neuron responses in humans during execution and observation of actions– Mukamel, R., Ekstrom, A.D., Kaplan, J., Iacoboni, M. & Fried, I., Current Biology 2010

A neural substrate in the human hippocampus for linking successive events– Paz, R., Gelbard-Sagiv, H., Mukamel, R., Harel, M., Malach, R. & Fried, I., PNAS 2010

2008

Internally generated reactivation of single neurons in human hippocampus during free recall– Gelbard-Sagiv, H., Mukamel, R., Harel, M., Malach, R. & Fried, I., Science 2008

Interhemispheric correlations of slow spontaneous neuronal fluctuations revealed in human sensory cortex– Nir, Y., Mukamel, R., Dinstein, I., Privman, E., Harel, M., Fisch, L., Gelbard-Sagiv, H., Kipervasser, S., Andelman, F., Neufeld, M.Y., Kramer, U., Arieli, A., Fried, I. & Malach, R., Nature Neuroscience 2008

Human single-neuron responses at the threshold of conscious recognition– Quiroga, R.Q., Mukamel, R., Isham, E.A., Malach, R. & Fried, I., PNAS 2008

Ultra-fine frequency tuning revealed in single neurons of human auditory cortex– Bitterman, Y., Mukamel, R., Malach, R., Fried, I. & Nelken, I., Nature 2008

2007

Coupling between neuronal firing rate, gamma LFP, and BOLD fMRI is related to interneuronal correlations– Nir, Y., Fisch, L., Mukamel, R., Gelbard-Sagiv, H., Arieli, A., Fried, I. & Malach, R., Current Biology 2007

Enhanced category tuning revealed by intracranial electroencephalograms in high-order human visual areas– Privman, E., Nir, Y., Kramer, U., Kipervasser, S., Andelman, F., Neufeld, M.Y., Mukamel, R., Yeshurun, Y., Fried, I. & Malach, R., Journal of Neuroscience 2007

2005

Coupling between neuronal firing, field potentials, and FMRI in human auditory cortex– Mukamel, R., Gelbard, H., Arieli, A., Hasson, U., Fried, I. & Malach, R., Science 2005

2004

Enhanced temporal non-linearities in human object-related occipito-temporal cortex– Mukamel, R., Harel, M., Hendler, T. & Malach, R., Cerebral Cortex 2004

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